Shore Magic® Research

​​How pure is Shore Magic®?
The fish used to make Shore Magic® are not exposed to antibiotics and hormones like Farm raised fish or animals.
Shore Magic® Hydrolyzed Marine Collagen Protein Powder Is Made from Wild Deep Sea Fish.  Our Purity Standards Exceed the Standards of the USA, Europe, & Asia.
 
Hydrolyzed Collagen as a food supplement came about later than gelatin, once scientists learned to break the long chain triple helix protein into shorter pieces, and then to separate the 3 helices from each other. The resulting short individual peptides make up hydrolyzed collagen. Cleaving peptides into sections is known as hydrolysis.
 
DOSAGE Shore Magic® Hydrolyzed Collagen comes different sizes. Dosage may vary from 2 – 6 tablespoons per day, blended in water, coffee, tea, oatmeal, soup, juices, or yogurt.  We have a cookbook that gives you many different options. How much should you take?

  • Acute conditions, injuries, arthritis, etc.: 3 tablespoons twice a day.
  • Maintenance dose, or detox program: 2 tablespoons per day, 2 times per day if needed.
This is not a pharmaceutical – precise amounts are not critical. You could probably take a whole jar in one day with no adverse effects. But that would be wasteful. Maximum absorbed amount would be near 6 tablespoons per day, for most people.
 
ENZYMATIC HYDROLYSIS
The method for final hydrolysis of Shore Magic® Collagen, that everyone agrees is by far the best, is using proteolytic enzymes. Without heat and acids, the bio-compatible integrity of the finished molecules will be guaranteed.
In our version of hydrolyzed Shore Magic® Collagen, the enzyme process is done up to 6 hours on each batch. The results are very small peptides – averaging 3000 Daltons (compared to 45,000 Daltons which is the average weight on the market today) making Shore Magic® a much more biocompatible and absorbable Collagen. It is the long duration of hydrolysis that ensures that peptides are cleaved into these very small pieces, uniform within their range.
 
There have been almost no Collagen producers willing to go to the trouble of hydrolyzing only with enzymes for so many hours, because it is expensive and time-consuming to do so, and most people don’t know the difference.
 
Our company, Generation Joy, goes to that trouble to get the best building material for the body’s new collagen, which can then build lean muscle, rebuild damaged joints, and provide for the other Collagen deficiencies listed below.

Taken long-term, it is practically impossible not to benefit from such a supplement, even if there is some serious underlying pathology. Once the body is provided with usable building blocks for new collagen, often for the first time in years, so many systems can show improvement:
  • Lean Muscle Gain
  • Anxiety
  • Focus
  • Digestive health
  • Muscle Tone
  • Skin Toning and Thickening
  • Joint Rebuilding,
  • Help for Arthritis
  • Arterial Strengthening
  • Circulatory Health
  • Healthy Blood Pressure
  • Health for Veins
  • Helps Maintain Men’s Sexual Health
  • Thickening Hair and Nails, Darkening of Grey Hair.
  • Increased Energy from Musculoskeletal Surcharge
  • Organ Rebuilding: Heart, Prostate, Lungs, Liver, Kidneys, Blood Vessels, Etc.
Chronic problems that can improve include:
Osteoporosis, High Blood Pressure, Arthritis in Joints, Bladder Weakness, Obesity, Chronic Fatigue, IBS , Shallow Breathing,
Autoimmune Situations,
Skin Problems,  
Splitting Nails, Symptoms of A.D.D, Varicose Veins, Depression, Anxiety, Digestive Distress, Crones Disease, carpel tunnel, tennis elbow, vertebrae of neck and spine, sciatica.

Impossible? Why such a Lack of Publicity?
Why have we heard so little about the fantastic effects of Shore Magic® Collagen?
Well just think – if a natural food supplement is 100% clean, with NO SIDE EFFECTS and could have powerful therapeutic effects on any system dependent on Shore Magic® Collagen, WHO WOULD STUDY THAT?...
…Who Would Publish the Results? University Research Labs Funded by The Drug Companies?


Fortunately, Legitimate studies have recently been conducted, and the results are overwhelming! (See References).
 
MOLECULAR WEIGHT
We saw that one determinant of Hydrolyzed Shore Magic® Collagen’s ultimate quality is molecular weight, or size of the finished molecules. The unit of molecular weight is the Dalton, of course. The molecular weight of a batch of Collagen, although expressed as a single number in Daltons, is actually an average size within a range.
 
Commercial Collagens sold as food supplements today can run from 10,000 Daltons up to more than 50,000 Daltons, depending upon processing. The average is near 45,000. For optimum bioavailability, or uptake at the cellular level, small is better. The lower the number of Daltons, the smaller the molecule, the greater the bioavailability.
 
Below 2000 Daltons there would be too many free amino acids, which would give the collagen a very harsh taste. At 3000 Daltons, hydrolyzed Shore Magic® Collagen gives a neutral taste – no taste when mixed with your choice of food or beverage. This is the optimum molecular size for the best usefulness by the body.

Bioavailability is a prime criterion in evaluating any supplement, not just Collagen: how much of the supplement gets absorbed at the cellular level. Bioavailability is expressed as a percentage, the higher the better, meaning that the greatest percentage of the supplement enters the body’s cells.
 
Our Shore Magic® Hydrolyzed Collagen is in the 3000 Dalton range, which is more than 15x better than most. Its bioavailability is 90%, digested and absorbed. Other studies showed that Shore Magic® is 95% bioavailability by radio-assay testing.
 
By contrast, most health supplements sold in stores have very cheap ingredients, which result in very low bioavailability, perhaps 5% or even less. Many pills, as in most of the multi products, do not even dissolve at all and pass through the body intact. That would obviously be about a 0% bioavailability. Shore Magic® offers capsules with the same pure form of collagen for those who need the collagen in the pill form.
 
1) Shore Magic® Collagen for Weight Loss
The purified, high-protein content of Hydrolyzed Shore Magic® Collagen is known to be an effective, natural appetite suppressant, in which many clinical studies have proven the satiating effect to promote weight loss
 
Additionally, unlike some weight-loss-promoting products, Shore Magic® Hydrolyzed Collagen contains no fillers, hormones, acids and is not produced with any forms of harsh processing that may affect the normal functioning of your body. Shore Magic® Hydrolyzed Collagen has also proven to show a decrease in fats, avoiding clogging of the arteries and increased organ support.
 
Individuals can therefore benefit from losing weight by consuming edible Shore Magic® Collagen, due to a lessened desire to snack and helping the body feel naturally fuller for longer… without the nasty side effects!
 
BONUS: Got Cellulite/Loose Skin? 
Consuming Shore Magic® Collagen protein may reduce both the elasticity of loose skin and the visible appearance of cellulite during your weight-loss journey or anytime. This is due to the molecule being responsible for making the connective tissue in your skin, therefore able to thicken the skin and camouflage any irregularities!
 
2) Muscle Growth & Performance
Shore Magic® Collagen is a powerful molecule that promotes a multitude of benefits to assist the needs and demands for athletes, bodybuilders, andeveryday gym-goers.
 
Consuming Hydrolyzed Shore Magic® Collagen in the form of smoothies, protein shakes, pancakes etc., has the incredible ability to aid the promotion of a natural source of Creatine in the body – this is an amino acid essential for building new muscle post-exercise and provide bouts of energy.
 
How does it work?
Your muscles rely on a direct energy source to maintain a regular function in the body – this is provided through the breakdown of adenosine triphosphate   (ATP) in your cells. For this compound to be replaced to provide further energy, amino acids glycine, arginine and methionine are needed, which together form the Creatine molecule.
 
Where does Shore Magic® Collagen come in? …
Shore Magic® Collagen peptides contain two of the three amino acids needed to form a natural, energy-boosting Creatine source in the body. The glycine and arginine duo in Shore Magic® Collagen may aid the production of Creatine, therefore helping to increase physical performance through repeated bouts of exercise, in addition to Arginine helping promote increased muscle growth and maintain leaner muscle mass! Win, win!
 
3) Joint & Bone Strength
The high percentage of our bone mass that is made of up of collagen has significant control of how strong or weak our joints will be going about everyday life – especially those with an active lifestyle!
Not providing your body with the necessary essential amino acids it needs to build up the proteins required for support, will result in the break down of proteins in the body – not what you need when you’re trying to gain strength! This may have a domino effect in making your joints weak and force your bones to lose density.
 
On the other hand, nourishing your body with the amino acids from Shore Magic® will build up proteins needed to strengthen many parts of your body, allowing for:

  • Less aches and pains that could prevent any form of exercise.
  • An increased range of motion when lifting weights.
  • The strength to be able to increase the intensity of exercise/lift more and quick recovery time after exercise.

To put Shore Magic® Collagen into perspective, it has been proven safe to potentially aid the treatment of osteoarthritis.
 
4) Shore Magic® Collagen for Sleep/Anxiety 
A decent sleeping pattern can do miraculous things for our body! Besides the obvious factor of making you feel less tired and lethargic during the day, more sleep can increase the quality of your health, improve your everyday mood and perspective, your sex life and, although you’re eating the right food and living an active lifestyle – not getting enough sleep could be the reason you’re not losing weight…
 
Multi-tasking amino acid Glycine, has yet another benefit – the ability to help individuals who struggle to sleep or even worse, fall into the 30% of all humans who suffer with insomnia.
 
A study analyzing the effects of consuming glycine, in comparison to a placebo before bed, clearly shown the amino acid to reduce fatigue and have a tendency toward reduced sleepiness
 
Glycine in Shore Magic® Hydrolyzed Marine Collagen can also relieve stress and reduce anxiety due to it’s properties of being a neurotransmitter with the ability to promote therapeutic alterations in the body. These factors can lead to a decrease in stress, anxiety, and depression and again, promote a better night’s sleep.
 
Hormone Balance- 
Emerging research shows that the specific amino acids in Shore Magic® Collagen may help improve the amino acid balance in the body and support the body’s natural hormone production.
 
5) Shore Magic® Collagen for Digestion
A healthy digestive system is a great base for a happy and energetic lifestyle. Alternatively, a weak digestive system can result in feeling sluggish and lethargic, make you feel demotivated and it can additionally cause stomach pains – in other words, you won’t feel like exercising. Does this sound like you?
Shore Magic® Collagen can contribute to a healthier, less agitated digestive system due to soothing properties of one of the amino acids glycine.
 
Shore Magic® Collagen Digestion
Normal digestion breaks down protein into peptides and amino acids, which are then absorbed into the bloodstream.
For the collagen protein found in foods and most supplements to be utilized by the body, it must first be broken down many times by the digestive system, and then absorbed through the intestine into the blood in the precise form needed. It’s then reassembled into your collagen at the proper site. Protein digestion of dietary Collagen is often incomplete, resulting in some very large peptide chains. These long molecules are not well utilized in the body’s efforts to keep up with the declining production.
 
6. Anti-aging and Beauty
Hydrolyzed Fish Collagen contains much larger amounts of the amino acids glycine and proline than many other proteins. These amino acids are necessary for promoting healthy tissue growth of hair, skin, and nails. Recent studies in Europe and Japan have indicated the benefit of consuming 10 grams of hydrolyzed collagen to improve skin hydration and reduce the number of micro and deep wrinkles compared to a placebo. *
Shore Magic® helps heal scars, even keloid scars that are years old.
 
*  Sibilla S., An Overview of the Beneficial Effects of Hydrolyzed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies, The Open Nutraceutical Journal, February 2015, Vol. 8, 29-42. http://benthamopen.com/ABSTRACT/TONUTRAJ-8-29
 
Anti-aging Benefits.
  • Helps Reduce wrinkles and sagging.
  • Helps promote skin hydration and elasticity.
  • Helps promote healthy Joints.
  • Helps your hair and nails grow strong and thicker.
  • Supports lean muscle tissue and maintaining bone all over the body, including facial structure which aids in that natural, youthful look.
 
7. Pregnancy and Shore Magic®
Getting enough collagen while pregnant is critical because it provides essential proteins that our bodies utilize daily and that promote optimal health for a growing baby. Collagen helps to build and repair our bones, joint surfaces, skin, teeth, eyes, arteries, intervertebral disks, and much more. Collagen is needed to ensure a strong body and to help you to continually heal.
The glycine in collagen also helps the liver digest toxic substances. Pregnancy already puts a heavy load on the liver, and adding collagen can help your liver function a bit easier.
 
Because Shore Magic® collagen helps the elasticity of the skin, it may be the answer to stretch marks.
 
Collagen is very high in protein so great for meeting your protein needs in pregnancy. The collagen is also great for supporting the formation of connective tissues and soothing the gut. Although, we always recommend speaking with your physician regarding your specific health needs while pregnant and nursing.
 
8. Children and the Gut Brain Connection
It has been shown that collagen helps the gut heal. It helps leaky gut resolve.  When this happens, people see a change in behavioral symptoms and focus in children (and adults).  Collagen helps the body to set the stage for proper neurochemical production. Much of which happens in the gut.  Therefore children who have conditions that are on the autistic spectrum as well as adults with anxiety and depression can see a vast improvement with the use of Shore Magic®.
 
Children as young as One year old can safely ingest Shore Magic® collagen.  Although we always recommend speaking with your physician regarding your specific health needs.

 

 


 

SHORE MAGIC® COLLAGEN RESEARCH

Published Research:
Research published by the International Research Journal of Pharmacy, has shown that collagen peptide extracted from fish skins consisting of small peptide molecules has a superior bioavailability and digestibility compared to other collagen products due to lower molecular weight. Thanks to this low molecular weight, it is absorbed at a higher level through the intestinal barrier into the bloodstream and carried throughout the body, leading to collagen synthesis in the joint tissues, bones, skin dermis and many other essential body systems. Supplementing with Shore Magic® collagen peptides provide the body with essential amino acids necessary to manufacture and support collagen. Additionally, marine collagen offers high amounts of nonessential amino acids like glycine and proline, which may not be produced in sufficient amounts as we age and are essential for the collagen regeneration cycle and specific nutritional needs.
 
Published Studies:
Studies published by the Journal of Agricultural and Food Chemistry explain the effect of hydroxyproline in human blood. When Shore Magic® collagen peptides are ingested, hydroxyproline peptides such as Pro-Hyp or Hyp-Gly are not completely digested to free amino acids and can be detected in the blood. These hydroxyproline peptides stimulate cells in the skin, joints and bones, and lead to collagen synthesis through cell activation, suppression and growth.

Because Shore Magic® Collagen is extracted from fish, it is free from bovine spongiform encephalopathy (BSE), foot-and-mouth disease and bird virus.

Allergen-Free Profile
During the manufacturing process, allergens are removed through a carefully controlled washing procedure, resulting in a hydrolyzed fish collagen free of allergens. Clinical trials were conducted to evaluate the allergenicity of food-grade fish collagen. A randomized, double-blind, placebo-controlled oral challenge study, published by the Food and Chemical Toxicology Journal, reported that fish-allergic patients did not develop any observable allergic reactions to hydrolyzed fish collagen.

Fish Origin
Fish-derived collagen is globally the preferred choice for collagen due to dietary, lifestyle or religious preferences for marine products over beef, pork, and chicken. Shore Magic® is all-natural, odorless, colorless, and tasteless for an extremely high degree of purity compared to other forms of collagen.

Skin Health
Shore Magic® Collagen is a key component for radiant, healthy skin, and maintaining the integrity of the extracellular matrix is essential for a youthful skin appearance. Collagen is one of the most important structural substances in our bodies, accounting for 25% to 30% of our bodies’ total protein and 75% of our skin. Shore Magic® Marine collagen peptides have been shown to effectively penetrate the stratum corneum to the epidermis and dermis, contribute to the activation of fibroblasts and accelerate collagen synthesis. Shore Magic® Collagen peptides can have a profound effect on the biological regulation of the skin and have been shown to boost new collagen production.

Bone Health
Bone health is vitally important as we age. During the aging process bone health problems cause discomfort, pain, and a host of other comorbidities. In the elderly, particularly, the amount of daily intake of protein can be suboptimal and can contribute to osteoporosis, a condition characterized by low bone mineral density and associated with increased risk of fracture. As we age, the balance between bone resorption and formation is compromised, resulting in a net loss of bone tissues. Ingestion of Shore Magic® collagen has been shown to stimulate osteoblast formation and help build new bone and restore bone density loss.
 
Joint Health
A wide range of studies have established marine collagen’s role in promoting joint health by helping to repair joint matrix degeneration and improving long-term joint comfort and mobility. Numerous studies have linked marine collagen peptides to improving joint conditions. Damage over time and the degradation of cartilage are linked to the breakdown of cartilage, entirely made of chondrocyte cells. Shore Magic® Collagen may help regulate chondrocyte differentiation and play a key role in the maintenance of established chondrocytes in cartilage.

Anti-Aging
Protein Enrichment, Performance Nutrition, and Anti-Aging
For athletes and active consumers alike trying to maintain a healthy lifestyle, Shore Magic® collagen plays a vital role for peak performance levels. Protein and specifically Shore Magic® collagen peptides deliver numerous health benefits way beyond muscle building. These include improving performance, supporting healthy joint and connective tissues, and preserving muscle.
With their unique amino acid profile, Shore Magic® Collagen peptides contain high levels of the amino acids glycine, hydroxyproline and proline, providing nutritional benefits not found in other protein sources. As a bioactive protein, Shore Magic® can help maintain the nitrogen balance and protect lean body mass.

Effectiveness of Hydrolyzed Marine Collagen is Demonstrated in Scientific Studies.
As one of the most widely researched collagen peptides on the market, marine collagen is supported by a notable amount of scientific evidence. Clinical research into collagen peptide benefits began over 40 years ago, and has expanded over the past decade. The results are a compelling body of scientific substantiation. Collagen’s benefits, bioavailability and efficacy have been demonstrated in double-blind, placebo-controlled clinical studies and published in leading scientific journals.
Studies support that Shore Magic® collagen peptides extracted from fish consist of small peptide molecules that have a superior bioavailability and digestibility compared to other collagen products.
Due to lower molecular weight, it is absorbed at a higher level through the intestinal barrier into the bloodstream and carried throughout the body, leading to collagen synthesis in the joint tissues, bones, and skin dermis.
Collagen peptides from marine sources have an amino acid composition that reveals a higher concentration of glycine, proline and hydroxyproline, which can be detected in the blood after ingestion. Protein is mostly digested and absorbed as amino acids. Glycine represents about one-third of the amino acid in collagen peptides and is known to play various roles, including functioning as a neurotransmitter. It is also a precursor for synthesis of heme and glutathione, as well as proteins in the body.
Clinical research has shown collagen to be partly absorbed in peptide form. For instance, the dipeptide prolyl-hydroxyproline (Pro-Hyp) is the main peptide component appearing in the body after collagen peptide ingestion. This specific dipeptide was reported to increase the number and the growth of cells spreading from skin in studies done on mice. Peptides resulting from collagen digestion are also chemoattractants for fibroblasts and may play a part in the stimulation of those cells that synthesize new collagen fibers (Shigemura, et al.). Collagen degradation peptides might attract these cells and result in repair of damaged tissue (Dybba, et al.).  Furthermore, growth of these cells was also enhanced significantly by Pro-Hyp. These studies suggest that ingested collagen peptide exhibits its effects on health through mechanisms unique to collagen peptides.

Consequently, Shore Magic® collagen has unique properties that are not found in other proteins, and these properties may be the reason for the effects of collagen peptide ingestion on bones, joints, skin, hair, and nails. 

Excellent Absorption and Digestibility
Results confirm that collagen is effectively absorbed into the blood. Several in vivo studies demonstrate the high bioavailability of collagen peptides with the use of marker collagen peptides. When present in the blood, collagen peptides will efficiently reach the target tissues, where they act as building blocks for the cells and help boost the production of new collagen fibers.

Shore Magic® Collagen is also at the forefront of new research on marine collagen. The studies listed below were selected from many references to give evidence of the wide range of published investigations and clinical research that can be found on collagen’s mechanism of action (MOA).

shore-magic-research

Science Review: RESEARCH, ALLERGEN-FREE, SKIN HEALTH, FISH ORIGIN

  1. Hayamizu K, et al. Effect of the collagen peptide drinks on the elastic properties of facial skin in normal volunteers. J New Rem Clin, Japan. 2000;49(9):867–873.
  2. Koyama Y. Effects of collagen peptide ingestion on the skin. Shokuhin-To-Kaihatsu. 2009;44:10–12 (in Japanese).
  3. Koyama Y, et al. Effects of oral ingestion of collagen peptide on the skin. Nippi Research Institute BioMatrix, Japan, 2006.
  4. Kuroda K, Utani A, Hamasaki Y, Shinkai H. Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts. J Dermatol Sci. 2001;26:156–160.
  5. Laskin DL, Kimura T, Sakakibara S, Riley DJ, Berg RA. Chemotactic activity of collagen-like polypeptides for human peripheral blood neutrophils. J Luekocyte Biol. 1986;39:255–266.
  6. Matsuda N, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol. 2006;52:211–215.
  7. Matsumoto H, Ohara H, Ito K, Nakamura Y, Takahashi S. Clinical effects of fish type I collagen hydrolysate on skin properties. ITE Letters. 2006;7:386–390.
  8. Morganti P, et al. Oral treatment of skin dryness. Cosmet Toilet. 1988;103:77–80.
  9. Palmer H, Maher VM, McCormik JJ. Platelet-derived growth factor and basic fibroblast growth factor induce anchorage-independent growth of human fibroblasts. J Cell Physiol. 1988;137:588–592.
  10. Postlethwaite AE, Kang A. Collagen and collagen peptide-induced chemotaxis of human blood monocytes. J Exp Med. 1976;143:1299–1307.
  11. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA. 1978;75:871–875.
  12. Rosenberg S, et al. Further studies in the use of gelatin in the treatment of brittle nails. Arch Dermat & Syph. 1957;76:330–335.
  13. Ruehl M, Somasundaram R, Schoenfelder I, et al. The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline. J Biol Chem. 2002;277:26872–26878.
  14. Scala J, et al. Effect of daily gelatine ingestion on human scalp hair. Nutr Rep Int. 1976;13:579–592.
  15. Schwimmer M, Mulinos MG. Salutary effects of gelatin on nail defects in normal subjects. Antibiotic Med Clin Ther. 1957;4:403–407.
  16. Shigemura Y, et al. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. 2009;57:444–449.
  17. Shigemura Y, Sato K. Ann Meet Jap Soc Biosci Biotechnol Agrochem, 2008 (Kansai div).
  18. Sumida E, et al. The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood. J Nutr Food. 2004;7:1–8.
  19. Sumida E, et al. The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood. J Nutr Food. 2004;7:45–52.
  20. Takahashi S. Collagen & Amino Acids Study. Meiji Seika Health & Bioscience Institute, 2008.
  21. Tanaka M, et al. Effects of collagen peptide ingestion on UV-B induced skin damage. Biosci Biotechnol Biochem. 2009;73:930–932.
 
Science Review BONE HEALTH
  1. Koyama Y, et al. Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition. J Nutr Sci Vitaminol. 2001;47:84–86.
  2. Mano H. Action mechanism of collagen peptide on bone, cartilage and joint. 1st Symp collagen peptide, Tokyo, Japan, 2009.
  3. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000;30:87–99.
  4. Nakatani S, et al. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse cartilage in vitro and in vivo. Osteoarth Cart. 2009;17:1620–1627.
  5. Nomura Y, et al. Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition. 2005;21:1120–1126.
  6. Wu J, et al. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab. 2004;22:547–553.
 
Science Review: JOINT HEALTH
  1. Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006 Nov;22(11):2221-32.
  2. Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009;60 Suppl 2:99-113.
  3. Bruyère O, Zegels B, Leonori L, et al. Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study. Complement Ther Med. 2012;20(3):124-30.
  4. Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008;24(5):1485-96.
  5. Daneault A, et al. Biological effect of hydrolyzed collagen on bone metabolism. Crit Rev Food Sci Nutr. 2015;10:1040–8398.
  6. Daneault A, et al. Hydrolyzed collagen contributes to osteoblast differentiation in vitro and subsequent bone health in vivo. Osteoarth Cart. 2014;22:S131.
  7. Guillerminet F, et al. Collagen peptides improve bone metabolism and biomechanical parameters in ovariectomized mice: an in-vitro and in vivo study. Bone. 2010;46:827–834.
  8. Guillerminet F, et al. Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporos Int. 2012;23(7):1909–1919.
  9. Iwai K, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005;53:6531–6536.
  10. Jiang JX, et al. Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro Food Ind Hi Tech. 2014;25:19–23.
  11. Kobayashi, et al. Ingestion of collagen in the course of daily life. 63rd Ann Meet Jap Soc Nutr Food Sci, Nagasaki, Japan, 2009 (in Japanese).
  12. Laskin DL, Kimura T, Sakakibara S, Riley DJ, Berg RA. Chemotactic activity of collagen-like polypeptides for human peripheral blood neutrophils. J Luekocyte Biol. 1986;39:255–266.
  13. Matsuda N, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol. 2006;52:211–215.
  14. McAlindon TE, Nuite M, Krishnan N, et al. Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. Osteoarthritis Cartilage. 2011;19(4):399-405.
  15. Minaguchi J, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol. 2005;51:169–174.
  16. Moskowiz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arth Rheum. 2000;30:97–99.
  17. Nakatani S, et al. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarth Cart. 2009;17:1620–1627.
  18. Postlethwaite AE, Kang A. Collagen and collagen peptide-induced chemotaxis of human blood monocytes. J Exp Med. 1976;143:1299–1307.
  19. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA. 1978;75:871–875.
  20. Prockop DJ, Keiser HR, Sjoerdsma A. Gastrointestinal absorption and renal excretion of hydroxyproline peptides. Lancet. 1962;2:527–528.
 
Science Review: ANTI-AGING
  1. Adibi SA. Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Am J Physiol Gastrointest Liver Physiol. 2003;285:G779–G788.
  2. Greenwel P, Hu W, Kohanski RA, Ramirez F. Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor b1 stimulation of a2(I) collagen gene expression. Mol Cell Biol. 1995;15:6813–6819.
  3. Hays NP, Kim H, Wells AM, Kajkenova O, Evans WJ. Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women. J Am Diet Assoc. 2009 Jun;109(6):1082–7.
  4. Kuroda K, Utani A, Hamasaki Y, Shinkai H. Platelet GpVI and mediates platelet activation by collagen. Cardiovascular Res. 1999; 41:450–457.
 
Science Review: SCIENTIFIC STUDIES, ABSORBTION & DIGESTION
  1. Ichikawa S, et al. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate. Int J Food Sci Nutr. 2010;61(1):52–60.
  2. Iwai K, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005;53:6531–6536.
  3. Laskin DL, Kimura T, Sakakibara S, Riley DJ, Berg RA. Chemotactic activity of collagen-like polypeptides for human peripheral blood neutrophils. J Luekocyte Biol. 1986;39:255–266.
  4. Mano H. Action mechanism of collagen peptide on bone, cartilage and joint. 1st Symp collagen peptide, Tokyo, Japan, 2009.
  5. Postlethwaite AE, Kang A. Collagen and collagen peptide-induced chemotaxis of human blood monocytes. J Exp Med. 1976;143:1299–1307.
  6. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci USA. 1978;75:871–875.
  7. Prockop DJ, Keiser HR, Sjoerdsma A. Gastrointestinal absorption and renal excretion of hydroxyproline peptides. Lancet. 1962;2:527–528.
  8. Ratnayake WMN, et al. Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. Br J Nutr. 1997;78:459–467.
  9. Rose ML, et al. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis. 1999;30:793–798.
  10. Shigemura Y, et al. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. 2009;57:444–449.
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